Nanomaterials for Tumor Targeting Theranostics:A Proactive Clinical Perspective

肿瘤靶向诊治纳米材料:前瞻性临床展望(英文版)

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Author: Mingqian-Tan & Aiguo-Wu
Language: Chinese and English bilingual
ISBN/ISSN: 9787040429244
Published on: 2015-12
Hardcover

本书是作者根据多年来从事肿瘤靶向诊治纳米材料的研究成果并结合国内外相关领域发展而撰写的一部学术专著。全书以多功能纳米材料的制备、应用为主线,全面、系统地介绍了磁性纳米材料、半导体量子点材料、介孔硅纳米材料、聚合物纳米材料、碳基纳米材料、金纳米材料、稀土上转换纳米材料、生物仿生多肽及树状分子等功能性纳米材料在肿瘤及生物医学成像、诊断和靶向治疗一体化方面的应用,并结合相关的研究前沿展望了其发展趋势。书中着重从基础科学的角度理解功能性纳米材料及其应用,目的是使研究者,尤其是初学者,阅读本书后能够对功能性纳米材料在生物医学诊治,尤其是在肿瘤的靶向诊疗一体化方面有一个比较全面的认识,进而掌握并拓展其应用领域。期望本书能够加深读者对肿瘤的靶向有效诊治及个性化诊疗的兴趣,引发更深入的探究。
本书可供影像学、医学工程、化学、材料及临床医学等领域,尤其是从事纳米生物、纳米医学、临床影像学等领域的科技工作者和工程技术人员参考,也可供高等院校、科研院所等相关专业的教师和研究生参考。


Foreword 
Foreword 
Preface 
Chapter 1 Nanomaterials as Therapeutic/lmaging Agent Delivery Vehicles for Wmor Targeting Theranostics 
1.1 Introduction 
1.2 Strategies for Nanomaterials as Delivery Vehicles for Tumor Theranostics 
1.3 Targeting Effects of Nanomaterials 
1.3.1 Passive Targeting 
1.3.2 Active Targeting 
1.4 Multifunctional Theranostic Systems 
1.4.1 Medical Imaging Modalities 
1.4.2 Magnetic Nanomaterials 
1.4.3 Quantum Dots 
1.4.4 Mesoporous Silica Nanoparticles 
1.4.5 SERS Gold/Silver Nanomaterials 
1.4.6 Polymeric Nanosystems 
1.4.7 Carbon Nanomaterials 
1.4.8 Lipopolyplex Nanoparticles 
1.4.9 NanolMicrobubbles 
1.4.10 Upconversion Nanomaterials 
1.4.11 Protein Nanomaterials 
1.5 Conclusions and Future Perspective 
Acknowledgments 
References 
Chapter 2 Basics of Theranostics in Tumor 
2.1 Introduction 
2.2 Nanoplatforms 
2.3 Nanoprobes 
2.4 Nanocarriers 
2.5 Nanodiagnostics 
2.6 Safety Issues and Future Direction References 
Chapter 3 Magnetic Nanomaterials for Tumor Targeting Theranostics 
3.1 Introduction 
3.2 Paramagnetic Nanomaterials for Theranostics 
3.2.1 Introduction to Magnetic Resonance Imaging and Paramagnetic Nanomaterials 
3.2.2 Synthesis of Paramagnetic Nanomaterials 
3.2.3 Paramagnetic Nanomaterials for Tumor Targeting Diagnosis 
3.2.4 Paramagnetic Nanomaterials for Tumor Targeting Theranostics 
3.2.5 Overview 
3.3 Superparamagnetic Nanomaterials for Theranostics 
3.3.1 Introduction to Superparamagnetic Nanomaterials 
3.3.2 Synthesis of Superparamagnetic Nanomaterials 
3.3.3 Superparz Letic Nanomaterials for.aramagneti Bioimaging 
3.3.4 Superparamagnetic Nanomaterials for Theranostics 
3.3.5 Overview 
3.4 Outlook 
Acknowledgments 
References 
Chapter 4 Quantum Dots (QDs) for Tumor Targeting Theranostics 
4.1 Introduction 
4.1.1 Fluorescence of QDs 
4.1.2 History of QDs and Their Biomedical Applications 
4.2 Synthesis, Modification and Functionalization of QDs 
4.2.1 Synthesis of QDs 
4.2.2 Surface Modification 
4.2.3 Functionalization 
4.3 QDs for Bioimaging 
4.3.1 In VitroImaging 
4.3.2 In, Vivo Imaging 
4.3.3 Cancerlmaging 
4.4 QDs for Theranostics 
4.4.1 QDs for Gene Delivery 
4.4.2 QDs for Drug Delivery 
4.4.3 QDs for Photodynamic Therapy 
4.5 Biosafety of QDs 
4.5.1 Cellular Uptake Mechanisms of QDs 
4.5.2 Cytotoxicity of QDs 
4.5.3 In, Vivo Fate and Toxicity of QDs 
4.6 Outlook 
References 
Chapter 5 Mesoporous Silica Nanoparticles (MSNs) for 
Cancer Theranostics 
5.1 Traditional Nanocarriers and Current Challenges 
5.2 Design of MSNs 
5.2.1 Why Use MSNs? 
5.2.2 Synthesis 
5.2.3 Surface Modification 
5.2.4 Cellular Uptake/Exocytosis/Biocompatibility/Biodistribution 
5.3 MSNs as a Drug Carrier 
5.3.1 Anticancer Drugs Delivery 
5.3.2 Cargo Release 
5.4 MSNs as Theranostic Agents 
5.4.1 Diagnostic Applications of MSNs 
5.4.2 Therapeutic Applications of MSNs 
5.4.3 Gene Delivery System 
5.5 Multifunctional Design of MSNs 
5.5.1 Hybrid Materials 
5.5.2 Core—shell Particles 
5.5.3 Multifunctional MSNs 
5.6 Future Perspective 
References 
Chapter 6 Surface Enhanced Raman Scattering (SERS) 
Nanoprobes as Cancer Theranostics 
6.1 Introduction 
6.1.1 Raman Scattering 
6.1.2 Resonance Raman Scattering 
6.1.3 Localized Surface Plasmons and SERS 
6.2 Development of NPs Based SERS Probe 
6.2.1 SERS NPs Made of Single Pure PlasmonSupporting Metals 
6.2.2 Bimetallic SERS NPs 
6.2.3 Dielectric—metal Complex SERS NPs 
6.2.4 NPs Decorated Carbon Material as SERSProbe 
6.2.5 Other SERS Probes 
6.3 SERS Theranostics 
6.3.1 Advantages of SERS Theranostics 
6.3.2 Encoding of SERS Nanoprobes and Modification for Targeting Bio—analytes 
6.3.3 SERS Theranostics: Current State 
6.4 Limitation and Future Development 
References 
Chapter 7 Polymeric Nanosystems for Targeted Theranostics 
7.1 Introduction 
7.2 Merits of Polymeric Nanosystem 
7.2.1 Potential Biocompatibility 
7.2.2 Easy Functionality 
7.2.3 Passive and Active Targeting 
7.3 Polymer Entities for Nanosystem Design 
7.3.1 PEG Derivatives 
7.3.2 Polypeptide 
7.3.3 Biopolymer 
7.4 Polymeric Nanosystems for Theranostics 
7.4.1 Polymeric Theranostics for MRI and Drug Delivery 
7.4.2 Polymeric Theranostics for US Imaging and Drug Delivery 
7.4.3 Polymeric Theranostics for Opticallmagingand Drug Delivery 
7.4.4 Polymeric Theranostics for Dual—imaging and Drug Delivery 
7.5 Perspectives and Concluding Remarks 
References 
…… 
Chapter 8 Carbon Nanomaterials for Tumor Targeting Theranostics 
Chapter 9 Lipopolyplex Nanoparticles for Tumor Targeting Theranostics 
Chapter 10 Microbubbles for Tumor Targeting Theranostics 
Chapter 11 Upconversion Nanomaterials for Tumor Targeting Theranostics 
Chapter 12 Functional Dendrimers as Nanoscale Theranostic Vehicles for Cnacer Treatment 
Chapter 13 Protein—based Nanporaticles for Tumor Targeting Theranostics 
Chapter 14 Conclusions and Future Perspectives 
Abbreviation Index 
Color Figures


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